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Synthesis of some Novel Quinazolinone Derivatives

P. Muthumani, R. Meera, Nandhakumar, P. Devi and B. Kameswari

In this work, an efficient two step synthesis for the preparation of some novel quinozolinones has been reported. In step I, various 2-substituted-3, 1-benzoxazin-4-ones are formed by the reaction of anthranilic acid and acetic anhydride / benzoyl chloride / propionic anhydride. In step II, 2-substituted-3, 1-benzoxazin-4-ones, which are formed in step I, are condensed with valdecoxib. The resulting quinazolinone derivatives were characterized by IR, NMR, 13C NMR and mass spectral analysis.