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Synthesis of Some New Thiophenes as Anti-Inflammatory and Antimicrobial Agent

Sajal Srivastava, Barnali Das and Y. Rajendra Prasad

A new series of 2-[(substituted benzylidene)imino]-3-(N-methylcarboxamido)-4,5-trimethylene thiophenes were synthesized by the reaction of cyclic ketone with cyanoacetamide in strong basic medium followed by Schiff base formation. Then newly synthesized compounds were characterized by IR spectroscopy, 1 H NMR and mass spectral data. The newly synthesized compounds were screened for antifungal and antibacterial and anti-inflammatory activities. Among them ss8e and ss8m exhibited good antifungal and antibacterial activities and ss8f & ss8e showed promising anti-inflammatory activity.