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Synthesis of antimicrobial, antioxidant and insect antifeedant potent 3,4-dimethyl phenyl bicycle[2.2.1] heptane methanone derivatives

G.Thirunarayanan

A series containing eleven (3,4-dimethylphenyl-3-(substituted phenyl) bicyclo[2.2.1]hept-5-ene-2-yl) methanones have been synthesized by an aqueous phase fly-ash catalyzed [4+2] cycloaddition Diels-Alder reaction of cyclopentadiene and 3,4-dimethyl phenyl chalcones under cooling condition. The yields of the methanones are greaterthan 60%. The synthesized 3,4-dimethyl phenyl bicyclo methanones were characterized by their physical constants and spectral data. The antimicrobial and antioxidant activities of the synthesized methanones were studied using a variety of bacterial and fungal strains and DPPH radical scavenging methods. The insect antifeedant activities of these methanones were studied with 4th instar larvae Achoea Janata L using leaf disc bio-assay method.