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Synthesis of 1-(2-Hydroxy-Aryl)-3-(5-Nitro-Thiophen-2-Yl)-Propenones Under Microwave and Antimicrobial Activity

N. J. P. Subhashini, Jampaiah Amanaganti and P. Acharya Nagarjuna

A series of 1-(2-hydroxy-aryl)-3-(5-nitro-thiophen-2-yl)-propenones were synthesized by Claisen-Schmidt condensation by 2-hydroxy acetophenes with 5-nitro-thiophene-2-carbaldehyde under both conventional and microwave irradiation methods. All the compounds were characterized by spectral data such as IR, 1 H NMR, 13C NMR and Mass spectrometry. The antimicrobial activities of 5-nitrothiophene-chalcones have been assessed by evaluating the zone of inhibition required to inhibit the growth of Escherichia coli, Klebsiella, Staphylococcus aureus and Basillus.