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Synthesis, design of triazinopyrimidines containing benzothiazole and benzoxazole derivatives as anticancer agents

Eman K.A.Abdelall, Abdou O.Abdelhamid

New series of cytotoxic agents triazolino[4,3-a]pyrimidines containing benzoxazole or benzothiazole moieties 4 and 5 were prepared from the reaction of each of 1-(2-(benzo[d]oxazol-2-yl)hydrazono)-1- chloropropan-2-one and 1-(2-(benzo[d]thiazol-2-yl)hydrazono)-1- chloropropan-2-one with certain pyrimidine thiones,. Some of the newly synthesized compounds were screened against certain cancer tumors.