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Synthesis, Characterization and Antibacterial Activity of N'-(2-Hydroxy-5-(Arylazo) Benzylidene-5-(Benzofuran-2-Yl)-1-Phenyl-1hpyrazole-3-Carbohydrazide Derivatives

Mohammad Idrees Roshan D. Nasareb and Naqui J. Siddiquia

A straight forward one pot two component synthesis of seven novel pyrazole based carbohydrazone derivatives has been described. Prominent feature of this synthetic process is a condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (2) with 2-hydroxy-5- (arylazo)benzaldehyde (1a-g) to afford directly N'-(2-hydroxy-5-(arylazo) benzylidene–5-(benzofuran-2- yl)-1-phenyl-1H-pyrazole-3-carbohydrazide derivatives (3a-g). The structural identities of carbohydrazone derivatives were confirmed by elemental analysis and spectral studies such as FT-IR, 1H NMR and Mass spectroscopy. The inhibitory effect of newly synthesized compound 3e was investigated in-vitro against Gram +ve and Gram -ve bacteria at different concentrations. 3e showed good to moderate inhibitory effects compared with standard drug Chloramphenicol. It was inactive against S. aureus and E. areogenes at a lower concentration of 31 μg/mL, while at rest of all the concentrations it showed inhibitory zone against used bacterial strains.