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Synthesis, Anti-HIV Activity and Cytotoxicity Studies of Novel 2-Phenyl, 3-substituted quinazolin-4(3H)-one Derivatives

P. Selvam, P. Babu, Padam Raj Rathore and Myriam Witvrouw

A series of novel 2, 3-disubstituted quinazolin-4(3H)-one derivatives have been synthesized by condensation of 2-substituted benzo[1, 3]oxazine-4-ones and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR, 1H-NMR, MS). Synthesized compounds were screened for in vitro antiviral activity against HIV-1(IIIB) in MT-4 cells. All the compounds displayed cytostatic properties in T lymphocytes cells and compounds QPABA and MSQN exhibited 19 and 16 percent maximum protection, respectively against HIV-1 at sub toxic concentration.