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Synthesis and evaluation of chalcone derivatives for its alpha amylase inhibitory activity

Makarand Attarde, Amisha Vora, Alice Varghese, Yusuf Kachwala

Chalcones represent a group of compounds with interesting biological activities that are formed from Claisen- Schmidt reaction between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst and ethanol as a solvent. Four different chalcones were synthesized using various substituted aldehydes as 4-nitrobenzaldehyde, 4-hydroxybenzaldehyde, 4-chlorobenzaldehyde, and 2-furfuraldehyde. The designed molecules were successfully synthesized in the laboratory using literature methods and structures were confirmed by NMR and IR spectroscopy. For anti-diabetic activity detection alpha amylase inhibitory assaywas carried out.According to the results obtained, it can be concluded that of the synthesized compound 3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one has anAlpha amylase inhibitory activity.