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Synthesis and Evaluation of 2-Mercaptothiazole-Propionic Acid Derivatives of Biological Interest

N. S. Mahajan, R. L. Jadhav, N. V. Pimpodkar, K. K. Mali and A. M. Manikrao

The title compounds have been synthesized from 4-phenyl-2-mercaptothiazole (I), which was synthesized by the reaction of phenacyl bromide and ammonium dithiocarbamate. This compound (I) on treatment with various N-substituted --chloropropionamide (II) furnishes the title compounds. The structures of these compounds were established on the basis of spectral data. All these compounds were screened for their antibacterial and antifungal activities. These compounds possessed moderate antibacterial and antifungal activities at compared with standard drugs.