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Synthesis and Characterization of Some Schiff Base Derivatives Containing Sydnone as Antimicrobial Agents

Savant SS, Patel SM, Gamit EA, Hajiyani HU, Patel SA, Patel PS and Patel KC

The series of Schiff base derivatives incorporating with Mannich base of 3-(3-nitrophenyl) sydnone were synthesized by conventional routes and evaluated for their antimicrobial activities against E. coli, P. aerugenosa, S. aureus, S. pyogenus, C. albicans, A. niger and A. clavatus. Most of the compounds showed moderate to very good biological activity. The structures of synthesized compounds 6a-j were elucidated by C, H, and N analysis, FT-IR, 1H NMR, 13C NMR and Mass Spectrometry.