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Synthesis and Characterization of Some Novel Sugar Containing -2, 4-Isodithiobiurets

Kavita M. Heda

A series of Novel 1-aryl-5-hepta-O-benzoyl-β-D-lactosyl-2-S-benzyl-2, 4-isodithiobiurets were synthesized by the interaction of 1-aryl-2-S-benzyl isothiocarbamides and hepta-O-benzoyl-β-D-lactosyl isothiocyanate in benzene medium. The identities of these newly synthesized N-lactosides have been established on the basis of usual chemical transformations and IR, 1H NMR and Mass spectral analysis. The polarimetric study of all compounds was carried out. The study of S-and N-glycosides is important in carbohydrate chemistry. Sugar isothiocyanate is good precursors and versatile intermediate for synthesis of S- and N-glycosides. Carbohydrates play an important role in the number of biological events and play an important role in their synthetic strategy as well. Similarly the amino sugars are an important class of glycosidase inhibitors and are arousing great interest as potential therapeutic agents.