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Synthesis and characterization of some new heterocyclic chalcones and their derivatives

Kishor Kapadia, Sejal Solankee, Yogesh Prajapati, Hiral Patel, Pankit Solankee, Anjani Solankee

Some newchalcones, 2-(4'-Chlorophenylamino)-4-(4'-fluorophenylamino)- 6-[4'-{3'Â’- (phenyl /susbstituted phenyl) -2’Â’-propenon-1’Â’-yl} phenylamino]- s-triazines (6a-e) have been synthesized by the Claisen-Schmidt condensation between ketone (5) based on s-trizine nucleus and different aromatic aldehydes. These chalcones (6a-e) on cyclisation with guanidine nitrate give aminopyrimidines (7a-e) and also on cyclisation with hydrazine hydrate in presence of glacial acetic acid give pyrazolines (8a-e). The structures of newly synthesized compounds have been characterized on the basis of elemental analysis,IR and 1H NMR spectra.