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Synthesis and characterization of 3, 4-dihydro-4(4-substituted aryl)-6-(naphtho [2, 1-b] furan-2-yl) pyrimidine-2[1H] thiones as potential antimicrobial agents

Sanjeevan S.Gaikwad, Venkat S.Suryawanshi, Dilip R.Kulkarni, Dhanaji V.Jadhav, Narayan D.Shinde

2-Acetylnaphtho [2, 1-b] furan (1) has been synthesized from2-hydroxy- 1-naphthaldehyde by reacting with chloroacetone, anhydrous potassium carbonate and dry acetone through Stoermer and Schaffer method. It was then converted to a series of substituted chalcones (2a-e) by Claisen- Schmidt condensation with substituted aromatic aldehydes in presence of aqueous potassium hydroxide solution. The resulting compound (2a-e) was treated with thiourea in presence of ethanol and concentrated hydrochloric acid yields the title compound. The structure of the compounds has been confirmed by elemental analysis and spectral studies and was screened for their antibacterial and antifungal activities.