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Synthesis and Antimicrobial Activity of Some Novel Imidazole Bearing Isoxazole Derivatives

Hitendra K. Maheta, Anil S. Patel and Yogesh T. Naliapara

A series of 1-(4-methoxybenzyl)-2-butyl-4-chloro-5-(3-arylisoxazol-5-yl)-1H-imidazoles (4a-l) were prepared by condensing 3-(1-(4-methoxybenzyl)-2-butyl-4-chloro-1H-imidazol-5-yl)-1-aryl-2-en-1- one (3a-l) with hydroxylamine hydrochloride in presence of 40% sodium hydroxide in methanol. Some of these compounds showed potential antimicrobial activity.