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Synthesis and Antimicrobial Activity of Some New 1-Substituted-3-Methyl-4-(Hydrazono)-2-pyrazolin-5-one

Sabir Hussain, Jyoti Sharma and Mohammad Amir

 Various-1-carbothioamide-3-methyl-4-(hydrazono)-2-pyrazolin-5-one (2a-f), 1-(pyridine-4- ylcarbonyl)-3-methyl-4-(hydrazono)-2-pyrazolin-5-one (3a-f), 1-(5-chloro-6-fluoro-1, 3-benzothiazole-2- yl)thiocarbamoyl-3-methyl-4-(hydrazono)-2-pyrazolin-5-one(4a-f) and 1-[(1, 2, 4-triazole-4-yl) carbothioamide]-3-methyl 4(hydrazono)-2-pyrazolin-5-one ( 5a-f ) were synthesized and evaluated for their antimicrobial activities. The compounds showed significant antibacterial and antifungal activity.