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Study on influence factors and experimental optimization for lipase-catalyzed enantioselective esterification of (±)-2-methyl-1-butanol

Qisong Liu, Yiwen Zhang, Quanyi Wang, Hang Song, Shun Yao

(±)-2-Methyl-butanol is a kind of useful solvent and important fine chemical. In this paper, related influence factors were investigated and response surface methodology was successfully applied to optimize lipase-catalyzed enantioselective esterification of (±)-2-methyl-butanol. The effects of were investigated. Then a quadratic polynomial regression model was used to analyze the experimental data at a 95%confidence level (p<0.05). The results indicated a significantly good fit to this model, and the response evaluated from the quadratic model showed a good agreement with the observed ones. The F-test and p-value indicated that reaction time, substrate molar ratio were the significant factors affecting the conversion of 2-methyl-butanol. The optimum reaction condition was established and the verified experimental trial was performed for validating the optimum points. Under the optimal condition, the conversion of (±)-2-methyl-butanol and the enantiomeric ratio exceeded 51.1%and 85.5%, respectively.