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Studies on Sustained Release Tablets of Aceclofenac: Formulation and in vitro Evaluation

S. Shanmugam, R. Manavalan and D. Venkappayya

The objective of the present study was to develop a sustained release matrix tablets of aceclofenac. The tablets were prepared with different ratios of hydroxypropylmethylcellulose K100 M and ethylcellulose by wet granulation technique.The granules were evaluated for angle of repose, bulk density and compressibility index. The prepared tablets were evaluated for hardness, friability, weight variation and drug content. The in vitro release of the matrix tablets were carried out using USP XXI apparatus with simulated gastric fluid (SGF, pH 1.2) followed by simulated intestinal fluid (SIF, pH 6.8) as the dissolution medium. The tablet properties complied with the official limits. The release of aceclofenac from tablets containing hydroxypropylmethylcellulose K100 M was completed within 12 h.