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STABPRO-A computational approach to protein stabilization

Padma V.Iyer, G.Raman

The present work envisages an approach to predict the effect of planned mutations in the amino acid sequences on stability of proteins using an application software named STABPRO, which was developed by the authors. The software predicts the effect of planned mutations on stability of a protein based on parameters such as hydrophobicity, steric volume, aliphatic- aromatic character, polar and non-polar residues that were present before and after the planned mutation. Further, four enzymes reported in literature for mutations were taken up for the demonstration of the software. It was found that the software correctly gave a quantitative prediction of the results given in literature.