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Spectroscopic characterization, theoretical treatment and antibacterial Co(II), Ni(II) and Zn(II) of phenazone derived NNO and NNN donor Schiff-bases

Omar Hamad Shehab Al-Obaidi

A series of biologically active phenazone (4-aminoantipyrine) – derived Schiff-base ligands have been synthesized by the condensation reaction of 4-aminoantipyrine with picolinaldehyde and furan-2-carbaldehyde. Then their Cobalt (II), Nickel (II) and Zinc (II) complexes have been prepared and characterized by different analytical and spectral methods: FT-IR, electronic spectral studies,magnetic susceptibilitymeasurements, atomic absorption,Molar conductivity measurements, molar ratio studies and melting points. The molar conductance measurements of the complexes inDMSO correspond to be electrolytic nature for all prepared complexes. On the basis of FT-IRand electronic spectral studies all complexes display an octahedral geometry around themetal center in (1:1) (L:M).Atheoretical treatment of the formation of complexes in the gas phase was studied, this was done using the HYPERCHEM-6 program for the Molecular mechanics and Semi-empirical calculations. The biological evaluation of the free ligand in comparison to their complexed have been determined against bacterial strains e.g., Escherichia coli and Staphylococcus. Finally, it was found that compounds show different activity of inhibition on growth of the bacteria.