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Spectrophotometric Estimation of Zidovudine in Bulks Samples and its Dosage forms

J. Sudhakar Reddy, Md. S. Maqsood Ahmed and I. E. Chakravarthy

A simple, sensitive and economical spectrophotometric method has been developed for the determination of zidovudine in commercial dosage forms. The method was based on the the charge transfer reactions of zidovudine as n-electron donor with acceptor, 2,5-dichloro-3,6-dihydroxy-1,4- benzoquinone. The absorbance of the highly intensive coloured solution was measured at 460 nm against reagent blank treated similarly. Statistical analysis proves that the proposed methods are reproducible and selective for the estimation of zidovudine in bulk drug and in its tablet dosage form.