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Spectrometric determination of irbesartan and hydrochlorothiazidin tablets by principal component regression and partial least squares calibration approach

Yasar Emir, A.HakanAktas

Two multivariate calibration-prediction techniques, principal component regression (PCR) and partial least squares (PLS) were applied to the spectrometricmulticomponent analysis of the drug containing Irbesartan (IRB) andHydrochlorothiazide (HCT) without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of IRBandHCTwere used to check the prediction ability of the PCR and PLS. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the two drugs.