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Simultaneous spectrophotometric determination of clomipraminehydrochloride in pure and pharmaceutical forms with some sulfonthalein dyes.

Samah A.Mohamed, Mohamed F.El-Shahat,Wagiha H.Mahmoud

A simple and sensitive spectrophotometric method has been developed for the determination of clomipramine hydrochloride (CPH) in pure and tablet dosage forms by ion-pair complex formation between sulphonphthalen dyes: clomipramine hydrochloride (CPH). The method was based on the ion pair formation of clomipramine with dyes. The method was based on the formation of ion-pair complex which was extracted and measured spectrophotometrically. The ion-pair chromogen being extractablewith chloroformcould be measured quantitively at 420nm against reagent blank treated similarly. BeerÂ’s law is obeyed in concentration range 2-24, 2-30, 1-10 and 2-25µg mL– 1 with correlation coefficient equal 0.996, 0.997, 0.995 and 0.999 with Bromophenol blue (BPB),Bromothymol blue (BTB),Bromocresol purple (BCP) and Bromocresol green (BCG) respectively and Effects of foreign ionswere also studied. Statistical analysis proves that the proposed method is reproducible and selective for the routine analysis of pharmaceutical formulations of Clomipramine