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Simultaneous Estimation of Cilostazol and Aspirin in Synthetic Mixture using HPTLC Method

Jayesh V. Patel, C. N. Patel, P. U. Patel, Pankaj H. Prajapati, I. S. Anand and M. B. Patel

A high performance thin layer chromatography (HPTLC) method was developed and validated for quantitative determination of cilostazol and aspirin in synthetic mixture. The analysis was performed using a mobile phase composed of methanol : ethyl acetate : toluene : solvent ether (1:2:2:0.5). The calibration graphs were linear correlation coefficient (r) > 0.995 in the studied concentration range of 100 to 800 ng/mL for cilostazole and 75-600 ng/mL for aspirin for HPTLC. Relative standard deviation of all the parameters for intraday and interday precision is less than 2% (0.75-1.25) and the accuracy was greater than 98%. So the proposed method is precise and accurate and can be applied directly and easily to the cilostazol and aspirin in synthetic mixture