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Simultaneous Determination of Atorvastatin and Ezetimibe by RP-HPLC in Pure and Pharmaceutical Dosage Form

B. Neelima, P. Ravi Kumar, M. Murali Krishna, V. Hima Bindu and Y. Rajendra Prasad

A simple, precise and rapid RP-HPLC method was developed for the simultaneous determination of atorvastatin and ezetimibe in combined pharmaceutical dosage forms. The method was carried out on a Shim-pack, RP-C18 column using a mixture of acetonitrile : 0.1% v/v orthophosphoric acid and detection was done at 239 nm using external standard method as quantitation. The linearity range of atorvastatin and ezetimibe were 0.1 to 25 =g/mL. The intra-day and inter-day precision were in the range of 0.55-0.91 and 0.62-0.87 for atorvastatin and 0.48-0.53 and 0.67-1.24 for ezetimibe.