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Simple and rapid spectrophotometric method for the estimation of erythromycin esters in pharmaceutical formulations

A.K.Shukla, Priti Mehta, R.V.Shah, R.C.Patel, Foram Makadia, Viral Siddhpura, Hiral Rathod

A simple and rapid method has been developed for the quantitative estimation of erythromycin esters in bulk and in pharmaceutical formulations. Erythromycin esters were found to react with o-nitro benzaldehyde in presence of acetic acid-hydrochloric acid mixture to form a colored product having useful absorption band at 486nm. Different variables affecting the color development were studied and optimized. The method was used to determine 10-50g/ml erythromycin in finalmeasured solution. The simplicity of the method permitted rapid analysis and it was suitable for routine control. In order to establish the validity of proposed procedure, commercially available Pharmaceutical formulations were analyzed. The reliability of the method was estimated by parallel determination against the reported method.