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Salvia Officinalis Infusion Improves Liver Antioxidant Status And Protects From Hypercholesterolemia

Hala M.EL-Desouki, Mouhamed A.Al-Omair

This study was aimed to determine the phytosterol components of Salvia officinalis infusion( sage tea ).Also, its antioxidant and hypocholesterolemic function. This study was performed on Swiss rats divided into 4 groups; normal control group I. Group II, inwhich animalswere fed on normal diet and received sage tea in a dose of 35mg/kg bw./day. Group III, where rats were maintained on high cholesterol diet for 4 weeks. Group IV, in which rats were maintained on high cholesterol diet while receiving sage tea in a dose of 35mg/kg bw./day for 4 weeks. Plasma transaminases, cholesterol, triglycerides, LDL, and lipidperoxides, liver GSH, and its related enzymes, glutathione-S-transferase(GST) and glutathione reductase(GR) activities were determined to study biosafety of sage and its protective effect against hypercholesterolemia. Sage tea exerted a significant decrease in total cholesterol, triglycerides, LDL, and lipid peroxides of ratsmaintained on high cholesterol diet, (Group IV) compared to group III,.p