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Reduction of á-Amino acids to chiral amino alcohols with potassium borohydride and aluminumchloride

Yu-Qing Cao, Fa-Yu Zhang, Shuai Nian

The formation of chiral amino alcohols by reduction of amino acids has been widely studied due to their important applications. á-Amino acids were reduced through KBH4/AlCl3 under mild or reflux reactions conditions , providing corresponding aminio alcohols in high yield and purity. It suggested that 1.4 equivalent of AlCl3 was adequate to reduce the amino acids to the corresponding â-amino alcohol. An improved, convenient procedure that reduces amino acids through KBH4/AlCl3 to the corresponding chiral amino alcohols in excellent yields under mild conditions has been found.