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Phase-transfer catalysis: A general green tactic in heterocyclic synthesis

Vijay V.Dabholkar, SagarD.Parab

The present work describes the use of phase transfer catalyst (PTC) for the synthesis of several heterocycles derived from secondary amine and different dihalides using TBAB (tetrabutylammonium bromide) as PTCs. Reaction of amine with dihalides suffered fromthe condensation. Utilizing a solid potassium carbonate as base and TBAB as PTC proved to be the best reaction conditions for amines and dihalides, which showed 100% conversion of secondary amine to the corresponding tertiary amine. The constitution of the products has been supported by element analyses, IR, NMR and Mass spectral data. To explore the role of PTC, we carried out modifying the catalyst nature and structure, temperature effect, different solvents and varying the concentration of the reactants and catalysts.