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Oxidative stress with homocysteine, lipoprotein (a) with lipid profile in amyloid nephropathy

Jyoti Dwivedi, Purnima Dey Sarkar

Secondary amyloidosis is awell known cause of nephrotic syndrome. Therefore, this study was carried out to investigate oxidant and antioxidant status in amyloid nephropathy patients. The blood samples were analyzed for quantitation ofmalondialdehyde as index of lipid peroxide, vitamin C, total antioxidant capacity, homocysteine lipoprotein (a) and lipid profile. Significantly increased levels of serumtotal cholesterol, triglycerides, lowdensity lipoprotein, lipid peroxide, lipoprotein (a), homocysteine (p<0.001) and decreased levels of serumtotal antioxidant capacity, high density lipoprotein, total protein, albumin, plasma vitamin C (p<0.001) were noticed in the patients with amyloid nephropathy as compared to control subjects.