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One-pot synthesis of spiro [indol- thiazolidinone]derivatives by three-component reaction of isatin, thioglycolic acid and amines catalyzed by oxalic acid

Zahed Karimi-Jaberi, Zahra Lotfi

Spiro-indolethiazolidinone derivatives are interesting heterocyclic compoundswhich showdiverse biological and pharmacological properties. In this research spiro-indolethiazolidinone derivatives was prepared by one-pot condensation reaction of isatin, thioglycolic acid and a number of amines using oxalic acid as a catalyst at room temperature.