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Molybdate sulfuric acid (MSA) an efficient catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles

Elham Mardani, Mina Haghdadi, Hassan Ghasemnejad-Bosra, Zohre Davodi

A simple highly versatile and efficient synthesis of 2,4,5-trisubstituted imidazoles is achieved by three-component cyclo condensation of 1,2- dicarbonyl compound, aldehyde and ammonium acetate using molybdate sulfuric acid (MSA) as a catalyst inmethanol atmoderate temperature. To explore the utility of this method 1,2,4,5-tetra-substitute imidazoles were also synthesized. The key advantages of this process are high yields, cost effectiveness of catalyst.