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Lupeol and lupeol esters protect the gastric ulcer in rats

V.Lakshmi, V.Mishra, G.Palit, S.Gupta, S.K.Agarwal

Objective: The lupeol isolated from the bioassay guided fractionation of the ethanol extract from the stem bark of the Crataeva nurvala, showed promising antiulcer effect in our random screening programme of natural products. Therefore we planned to make some derivatives of the lupeol, whichmay further enhance the antiulcer activity.Materials andmethods:A one-step synthesis of long chain fatty acid and aromatic esters derivative of the lupeol with different acid halides and acids were done. A series of esters derivatives of lupeol were prepared and bio assayed for the antiulcer activity in Cold restraint induced gastric ulcer(CRU). Results: Few derivatives of lupeol (Lupeol acetate, Lupeol toluate, Lupeol palmitate, Lupeol stearate,) showed more potent percentages of antiulcer activity in Cold restraint induced gastric ulcer model in rats (table-1) as compared to the basic molecule lupeol. Conclusion: In our studies it was found that the esters derivatives of lupeol posses better antiulcer activity as compared to lupeol. It is thus concluded that lupeol skeleton deserve further investigation for the development of more potent and non-toxic new antiulcer agents for its therapeutic use.