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Interleukin-6 levels after open and laparoscopic Nissen's fundoplication for gastro-oesophageal reflux disease: A short meta-analysis

M.R.S.Siddiqui, F.Hasan

Objectives:Ameta-analysis of published literature comparing interleukin- 6 (IL-6) levels after open NissenÂ’s fundoplication (ONF) versus laparoscopic NissenÂ’s fundoplication (LNF) for gastro-oesophageal reflux disease.Methods: Electronic databases were searched fromJanuary 1991 to October 2009. A systematic review was performed to obtain a summative outcome. Results: Two randomized controlled studies were analyzed. There were 30 patients in the laparoscopic group and 30 in the open group. There was no significant heterogeneity among trials (Q = 0.08, df = 1, p < 0.77, I2 = 0). There was no significant difference between LNF and ONF[fixed effectsmodel: SMD= -0.05, 95%CI (-0.54, 0.43), z = - 0.21, p = 0.83; randomeffectsmodel: SMD= -0.05, 95%CI (-0.54, 0.43), z = -0.21, p = 0.83]. Conclusions: There appears to be no difference in IL-6 levels after ONF or LNF in the immediate period after surgery, however there few studies and further randomized trials are needed to strengthen the evidence.