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Insilico Analysis of Cranberry Proanthocyanidin Catechin-(4 alpha- 2)-Phloroglucinol as an Inhibitor for Modeled Afimbrial Adhesin Virulence Protein of Uropathogenic Escherichia coli

Abhilash M, Shwetha PV and Sneha Prabha J

Fimbrial adhesion is a Virulence Determinant which is classified under Adhesins category of virulence factor of uropathogenic Escherichia coli. Afimbrial adhesin Proteinwith swissprot accession number P12730, of length 181 amino was selected formodeling usingBioinformatics tools.Modelled protein has been submitted to protein model database and has been assigned an accession number of PM0075877. Docking analysis of Catechin- (4 alpha-2)-phloroglucinol fromcranberry againstmodelled fimbrial adhesion was carried out using hex docking tool. Some of the commonly used antibiotics to treat urinary tract infections caused by Uropathogenic E.coli which includes Oflaxacin, sulfamethoxazole, Trimethoprimwere subjected to docking analysis for comparative studies.