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In Vitro Drug Release Profile of Aceclofenac Niosomes Formed with Different Ratio’s of Cholesterol using Sorbitan Esters

B. Divya, K. Venugopal, K. Ishwarya and R. Naganjaneyulu

Niosomes are non-ionic surfactant vesicles are microscopic lamellar structures formed on the admixture of non-ionic surfactant of alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Niosomes were formed using sorbitan esters (span 20, 40, 60 and 80) and cholesterol in different molar ratios. Acelofenac niosomes are formed using ether injection method. The so formed niosomes were evaluated for their in-vitro drug release and the best formulation with sustained drug release was formed with span-60. The mechanism of drug release was governed by peppas.