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Floating Microspheres of Repaglinide: Formulation, Optimization, Characterization and in Vitro Evaluation

Megha Sharma, Seema Kohli and Agnimitra Dinda

Drugs that are easily absorbed fro m the gastrointestinal tract (GIT ) and having short half life are eliminated quickly from blood circulation and need frequent dosing such as repaglinide. Therefore, floating microspheres of repaglinide were prepared using ethylcellulose (EC) alone and in combination with hydroxypropylmethylcellulose (HPMC) by solvent diffusion-evaporation technique. Various process variables were studied during formulation and their e ffect on various properties were recorded. Increase in stirring rate slightly increases the drug release and was found to be in the range of 70.2-86.3% for EC whereas 78.6-86.4% for EC: HPMC formulations. The mechanism of drug release was studied and found to follows first order kinetics. The regression of optimized formulations were found to be 0.926 (E6) and 0.955 (H9)