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Evaluation of Anti-inflammatory Activity of Roots of Atalantia monophylla

B. Ganga Rao, M. Sanjith Nath, G. V. Sampath Kumar and M. Samuel

The study was designed to evaluate the anti-inflammatory effect of methanolic and chloroform root extracts of Atalantia monophylla (Rutaceae), in carrageenan induced albino wistar rats of either sex (175-225 g).The anti-inflammatory effects of chloroform extract of Atalantia monophylla 200,400 mg/kg p.o were found to be significant in reducing rat paw oedema induced by carrageenan, where as methanolic extract produced significant reduction of paw oedema at 400 mg/kg p.o. Ibuprofen (50 mg/kg) was used as the reference anti-inflammatory agent for comparison. The chloroform extract was highly significant in reducing rat paw oedema. The result of this experimental animal study indicated that the extracts possess anti-inflammatory activity, and thus, lend credence to the suggested use of these plants in the management or control of arthritis and other inflammatory conditions in certain communities of India.