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Effect of methanolic extract of aerial parts of Merremia tridentata on gentamicin-induced nephrotoxicity in rats

Sreedevi Adikay, R.Radha, Bharathi Koganti

Methanolic extract of aerial parts of Merremia tridentata (300 & 600 mg/ kg, p.o.) was screened for its nephroprotector activity against gentamicininduced (40mg/kg) renal damage in curative and prophylacticmodels.Nephrotoxicity was assessed by measuring serum markers level (blood urea nitrogen, serum creatinine) and urinary protein excretion. Gentamicin-induced renal toxicity characterized by significant elevation of blood urea nitrogen, serum creatinine and high urinary protein excretion. Among the two regimens, more pronounced activity was observed in curative model. In curative model, methanolic extract showed dose dependent activity. Animalswhich received prophylactic treatment exhibitedmoderate protection against gentamicin-induced kidney damage. Present results suggested methanolic extract showed nephroprotector activity against gentamicininduced nephrotoxicity.