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Effect of compound-maqin-decoction on expression of th17/treg cytokines in asthmatic rats

Xie Yan-hong, Li Xue-liang, Xu Zhao-xia, Qian Peng, Li Xue-ping, Xu Jin

In the current study, asthma rats model replicated, and interventionwith CMD.After 4 weeks of treatment, detect the serum expression of TNF-α and IL-10 in rats, IL-22 and IL- 35 in lung homogenate. Compared with the normal group, the model group, dexamethasone group and small doses of TCM group rats serum TNF-αrise and IL-10 reduce, the difference was statistically significant, and no significant differences between with large doses of TCM group. After treatment, the serum TNF-αreduce and IL-10 rise, the difference between large doses of TCM group, model group and dexamethasone group was statistically significant. Compared with the normal group, the model group, each group tissue homogenate IL-22 rise and IL-35 reduce, the difference was statistical significant, and no significant differences between with large doses of TCM group. After treatment, the lung homogenate IL-22 reduce and IL-35 rise, the difference between large doses of TCM group, model group and dexamethasone group was statistically significant. These results showed that CMD maybe inhibit the generation of TNF-α, IL-35, and promote the body to release inflammatory cytokines like IL-10, IL-22, etc, to adjust the balance of Th17/Treg cells, reduce rats airway inflammatory reaction and relieve asthma symptoms.