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Development and Validation of UV Spectrophotometric Method for the Simultaneous Estimation of Trifluoperizine Hydrochloride and Trihexyphenidyl Hydrochloride in Combined Tablet Dosage Form

Sunil L. Dabhade, A. Satishkumar Shetty, B. Gopinath, Manzoor Ahmed, B. K. Sridhar and Mithun L. Sureja

A new simple, sensitive and specific spectrophotometric method has been developed for the simultaneous estimation of trifluoperazine hydrochloride and trihexyphenidyl hydrochloride in combined dosage form. The method involves solving simultaneous equation. Trifluoperazine hydrochloride has absorbance maxima at 257.5 nm in distilled water and trihexyphenidyl hydrochloride has absorbance maxima at 210 nm in distilled water.

The proposed method was validated in terms of linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. Beer’s law was obeyed in the concentration range of 2-15 μg/mL and 4-35 μg/mL for trifluoperazine hydrochloride and trihexyphenidyl hydrochloride, respectively and with regression coefficient r = 0.999 for both.