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Development and validation of new colorimetricmethod for the estimation of furazolidone in bulk and solid dosage form

Dhirender Singh Mittan, Pradeep Kumar, S.P.Venkatesh Prasad, Harikesh Kalonia, Sudhir Poria

A simple and sensitive spectroscopic method in ultraviolet region was developed and validated for the estimation of furazolidone in pure and pharmaceutical dosage forms by colourimetry method. The method is based on the reaction of Furazolidone with 2% w/v (2ml) solution of 4-nitro aniline reagent; the solution was heated on a water bath for 20 minute. After 20 minute 0.5 ml of 0.1Mpotassiumhydroxide (KOH) was added to yield colored chromogen. This color has characteristic of light absorption in the visible region, with absorption maximum at 455 nm. This method obey’s Beers law in the concentration range of 4 to 32 g/ml respectively. The proposed method is precise, accurate, linear, stable and reproducible and can be extended to the analysis of furazolidone in bulk and tablet formulations.