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Development and Validation of HPLC Analytical Assay Method for Mefenamic Acid Tablet (Ponstan)

Fouad Fadhil Al-Qaim, Md Pauzi Abdullah, Mohamed Rozali Othman and Wan Mohd Afiq Wan Mohd Khalik


Mefenamic acid is analgesic and anti-pyretic used to treat menstrual pain. A simple assay method by HPLC was developed and validated for mefenamic acid tablet (Ponstan). Analyses of mefenamic acid in a commercial tablet, Ponstan were performed using HPLC- Uv-Visbleat 275 nm on a reverse phase column Chromolith (RP-18e, 100 mm x 4.6 mm, 5 μm), a binary mobile phase; A: 0.1% formic acid in deionised water, B: 100% acetonitrile. The validation aspects were selectivity, linearity, precision, accuracy and quantification limit. Linearity, 5-250 mgL-1, provided determination coefficients (R2) of 0.9995, and proved precise since the RSD% was less than 5% for three replications analysis. The recoveries obtained ranged from 99% to 108%. In this study, the optimisation of mobile phase, flow rate, volume injection and wavelength were achieved through a statistical treatment. The retention time and drug content of mefenamic acid was 3.9 min and 97%, respectively. This method is precise, accurate and very simple to analysis mefenamic acid in tablets.


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  • CASS
  • கூகுள் ஸ்காலர்
  • ஜே கேட் திறக்கவும்
  • சீனாவின் தேசிய அறிவு உள்கட்டமைப்பு (CNKI)
  • CiteFactor
  • காஸ்மோஸ் IF
  • எலக்ட்ரானிக் ஜர்னல்ஸ் லைப்ரரி
  • டைரக்டரி ஆஃப் ரிசர்ச் ஜர்னல் இன்டெக்சிங் (DRJI)
  • ரகசிய தேடுபொறி ஆய்வகங்கள்
  • ICMJE

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