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Development and in vitro Characterization of Propranolol Hydrochloride Buccal Films

P. N. Krishnan, S. Sangeetha, D. Nagasamy Venkatesh and R. Saraswathi

Mucoadhesive buccal films of propranolol hydrochloride were prepared using three different polymers by solvent casting technique using mercury as a substrate. The buccal films were evaluated for various physicochemical parameters such as weight variation, thickness, folding endurance, drug content and in vitro bioadhesive strength. Different media namely, distilled water and simulated saliva solution were used for swelling study. The in vitro dissolution study of buccoadhesive formulations were performed using dialysis membrane method and the release was found to obey first order following anomalous diffusion.