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Detection of Conformation-Dependent Tumor Associated Antigens in Immune Complexes from Plasma of Mammary and Venereal Tumor Affected Dogs

Hari Mohan Saxena and Raman Chopra

Hyperimmune serum against intact whole immune complexes from mammary tumor affected dog gave strong positive reactivity in dot ELISA with plasma from dogs affected with mammary, venereal and other tumors compared to sera against the antigen - rich and the antibody - rich fractions of dissociated circulating immune complexes. These results suggest a possibility of existence of tumor associated antigens (TAAs) as conformation - dependent epitope (s) in circulating immune complexes in canine tumors.