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Density and viscosity studies of aspirin in aqueous ethanol systemat 301.5k

Mazahar Farooqui* Muktar Shaikh

Density and Viscosity of drugAspirin (APN) in various aqueousmixtures of ethanol have been determined. These results are further extended for solutes like electrolyte NaCl and non-electrolyte sucrose in the presence of this drug. The density and viscosity data have been analyzed for the evaluation of partial molar volume, molar excess volume, Gibbs free energy of viscous flow, excess viscosity and A and B viscosity coefficients using Jones-Dole equation. It can be inferred from these studies that this drug acts as a structure-making compound due to hydrophobic hydration of drug molecules. B-coefficients values are found to be positive thereby showing drug solvent interactions. Furthermore these results are correlated to understand the solution behavior of drug.