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Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line

Ignacio E.Len, Susana B.Etcheverry, Enrique J.Baran

The cytotoxicity activity of the recently reported [VO(H2O)2(SO4)dppz]2H2O complex (dppz = dipyrido[3,2-a:2ÂÂ’,3ÂÂ’- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 Mand diminished the cell viability ca. 40% in the range from 25 to 100 ìM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]3H2O (ODA= dianion of oxodiacetic acid) and [VO(ODA)(phen)]1.5H2O (phen = ophenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.