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Benzohydrazide incorporated Imidazo [1,2-b] pyridazine: Synthesis, Characterization and in vitro Anti-tubercular Activity

Paidi KR, Tatipamula VB, Kolli MK and Pedakotla VR

The accumulating pharmacological importance of drug resistant pathogens has lent auxiliary urgency to new anti-tubercular compound development. In this regard, a novel series of imidazo [1,2-b] pyridazine comprising benzohydrazide derivatives have been synthesized, characterized by using spectral data and screened for anti-tuberculosis activity. The anti-tubercular activity of the synthesized compounds (6a-l) was determined by microplate alamar blue assay and the outcomes were screened in vitro against Mycobacterium tuberculosis H37Rv strain. Compounds 6a-l exhibited good to potent anti-tubercular activity when compared with the standard first line anti- tuberculosis drugs (ciprofloxacin, pyrazinamide and streptomycin). Some of the tested compounds exhibited highest inhibitory activity at 1.6 μg/mL minimal inhibition concentration.