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Aquoeus extracts of rosmarinus officinalis, urtica diocia and soybean exert different effects on adenosine deaminase activity in cancerous and non cancerous human gastric and colon tissues

Zahide Esra Durak, Suleyman Buber, Hilmi Kocaoolu, Bahad�?�?�?�?�?�?�?½r OztUrk

This study aimed to investigate effects of aquoeus extracts of rosmarinus officinalis, urtica diocia and soybean on adenosine deaminase (ADA) activity in cancerous and non cancerous gastric and colon tissues. In method, cancerous and non cancerous human gastric and colon tissues removed by surgical operations were studied. In the samples, adenosine deaminase activities were measured with and without plant extract incubated for 1 h. As a result, it has been observed that rosemary extract inhibits ADA enzyme in cancerous and non cancerous gastric tissues, but not in colon tissues, and urtica extract inhibits the enzyme only in cancerous gastric tissue. On contrast, soybean extract activates ADA enzyme in colon tissues significantly. Inhibition of ADA enzyme might play a part in the proposed anti-cancer properties of rosemary and urtica diocia. However, the finding of ADA activation in colon tissues by soybean extract is a new one which needs further verification.