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Application of Microwave Induced Delepine Reaction to the Facile one Pot Synthesis of 7-Substituted 1, 3-Dihydro-2H-[1, 4]-Benzodiazepin-2-one-5-methyl Carboxylates from the Corresponding 1- Chloroacetyl Isatins

Pramila Sharma, Bharti Vashistha, Ruchi Tyagi, Vidushi Srivastava, Monica Shorey, Bhawani Singh and D. Kishore

Application of microwave induced Delepine reaction to the facile one pot synthesis of 7-(fluoro, chloro, bromo, iodo, methyl, methoxy, nitro) and 5, 7- dimethyl substituted, 1, 3- dihydro-2H-[1, 4] - benzodiazepin-2-one-5-methyl carboxylate derivatives 3(a-i) from the corresponding 1- chloroacetyl isatin 2(a-i) has been described. The mechanism involved in the microwave assisted Delepine reaction in the transformation of 2 to 3 has been disscussed.