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Anti-Nociceptive and Anti-Epileptic Evaluation of N-Mannich Bases of Some Substituted Carbazoles

V. Rajamanickam, A. Rajasekaren, M. Palanivelu, K. Anandarajagopal, A. L. Ashik Elahi and N. Umarani

N-Mannich bases of newly synthesized carbazole compounds were synthesized from carbazole by reacting with series of aldehyde like formaldehyde and acetaldehyde and the various secondary amines. Synthesized compounds were characterized by spectral studies and evaluated for antinociceptive and anti-epileptic activities by Eddy’s Hot plate method and maximum electrical shock induced convulsion method respectively. The statistical analysis was done by students “ t ”test and the values were expressed as mean ± SEM.